Alprazolam was significantly more toxic than other benzodiazepines. The increased prescription of alprazolam to groups with an increased risk of deliberate self.
Because this effect remains after adjustment for dose, co-ingested medication and age, this greater toxicity appears due to intrinsic toxicity of alprazolam. In addition, the pack size and packaging of alprazolam should be reviewed to decrease the risk of it being taken for deliberate self poisoning. In conclusion, our study demonstrates that alprazolam is relatively more toxic than other benzodiazepines. Alprazolam overdose should be regarded as more significant than other benzodiazepines.
The presentation of medications in terms of quantity available and packaging is important for the risk and severity of deliberate self poisoning.
There are some notable differences between Valium and Xanax, but also some similarities. Valium and Xanax are both benzodiazepines that can be used to treat.
However, researchers do know it is metabolised by the CYP2C19 group of hepatic enzymes. Approximay 15.7% of Asian people and 18.5% of African Americans have a slow metabolizing form of this enzyme. Both Valium and Xanax should only be used short-term due to risk of addiction and dependence. Benzodiazepine equivalency tables state that 0.5mg of alprazolam (Xanax) is approximay equivalent to 5mg diazepam (Valium).
Xanax was developed as a potential less addictive alternative to the benzodiazepine Valium because Xanax has a much shorter half-life than Valium;.
Individuals who use Xanax with other central nervous system depressants, such as alcohol, other benzodiazepines, or narcotic medications, are risking an increased potential for overdose because the combination of these drugs lowers the threshold needed to overdose on either class of drugs. Because the majority of individuals who abuse Xanax abuse it in conjunction with other drugs, there is a real potential for overdose.
For this reason benzodiazepines are classified by the United States Drug Enforcement Agency as Schedule IV drugs, meaning that they are believed to have a potential for abuse and physical dependence, and can only be purchased legally with a prescription from a physician.
Xanax is approved by the FDA for the treatment of anxiety disorders and panic disorders. Like all benzodiazepines, Xanax causes sedation and.
GABA is a protein in the brain called a neurotransmitter that tends to decrease the activity of nerve cells, leading to sedation among other effects. When Xanax and Ambien interact with GABA receptors, this increases the effects of GABA within the brain. They both act at proteins on the surface of nerve cells called gamma-aminobutyric acid (GABA) receptors. This difference may explain why Ambien is mainly effective as a sleep medication, whereas Xanax has antianxiety effects as well. Xanax and Ambien enhance sleep by affecting the body in a generally similar manner.